[Lactobacillus fermentum] Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

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Human MilkProbiotic Lactobacillus fermentum CECT5716 Reduces the Incidence ofGastrointestinal and Upper Respiratory Tract Infections in Infants

José Maldonado, FranciscoCanãbate, Luis Sempere, Francisco Vela, Ana R. Sánchez, Eduardo Narbona, EduardoLópez-Huertas, Arjan Geerlings, Antonio D. Valero, Mónica Olivares, andFederico Lara-Villoslada

Abstract

Objectives: The aim of the study was to examine the effects of a follow-on formula containing Lactobacillus fermentum CECT5716 (L fermentum) on the incidence of infections in infants between the ages of 6 and 12 months.

Patients and Methods: A randomized double-blinded controlled study including infants at the age of 6 months was conducted. Infants were assigned randomly to either follow-on formula supplemented with L fermentum plus galactooligosaccharide (experimental group, EG), or the same formula supplemented with only galactooligosaccharide (control group, CG). The main outcome was the incidence of infections for the 6-month duration of the study.

Results: The EG showed a significant 46% reduction in the incidence rate (IR) of gastrointestinal infections (EG: 0.196 Æ 0.51, CG: 0.363 Æ 0.53, IR ratio 0.54, 95% confidence interval [CI] 0.307–0.950, P ¼ 0.032), 27% reduction in the incidence of upper respiratory tract infections (EG: 0.969 Æ 0.96, CG: 1.330 Æ 1.23, IR ratio 0.729, 95% CI 0.46–1.38, P ¼ 0.026), and 30% reduction in the total number of infections (EG: 1.464 Æ 1.15, CG: 2.077 Æ 1.59, IR ratio 0.70, 95% CI 0.46–1.38, P ¼ 0.003), at the end of the study period compared with CG.

Conclusions: Administration of a follow-on formula with L fermentum CECT5716 may be useful for the prevention of community-acquired gastrointestinal and upper respiratory infections.

제목

모유의 프로바이오틱스 락토바실러스 퍼멘텀(Lactobacillus fermentum) CECT5716은 영아의 위장관 및 상부 호흡기 감염의 발병률을감소시킨다.

내용

목적: 이 연구의 목적은 L. fermentum CECT5716을함유한 분유가 생후 6개월에서 12개월 사이의 영아에서 감염의발생률에 미치는 영향을 조사하는 것이었다.

환자 및 방법: 생후 6개월의영아를 포함한 무작위 이중 맹검 대조 연구가 수행되었다. 영아들은 L. fermentum 발효액과 갈락토올리고당(galactooligosaccharide)이들어있는 분유를 제공받는 실험군 또는 갈락토올리고당만 첨가된 동일한 분유를 제공받는 대조군에 무작위로 배정되었다.주요 결과는 6개월간의 연구 기간 동안의 감염 발생률이었다.

결과: 실험군은 대조군과 비교하여 연구 종료 시점에 위장관 감염 발생률(IR)이 상당히 감소하였고 (실험군:0.196 ± 0.51, 대조군: 0.363 ± 0.53, IR 비율 0.54, 95 % 신뢰 구간 [CI] 0.307-0.950, P = 0.032),상부 호흡기 감염의 발생률이 27 % 감소하였으며 (실험군 : 0.969 ± 0.96, 대조군 : 1.330 ± 1.23, IR 비율 0.729, 95 % CI 0.46-1.38, P = 0.026), 총 호흡기 감염 수가 30% 감소 (실험군 : 1.464± 1.15, 대조군 : 2.077 ± 1.59, IR 비율 0.70, 95 % CI 0.46-1.38, P = 0.003)함을 보였다.

결론: L.fermentum CECT5716를 함유한 분유의 투여는 환경에서 얻는 위장관 및 상부 호흡기 감염을 예방하는 데 유용할 수있다.

Key Words

: #Follow-onFormula #Formula #Infants#Infection #LactobacillusFermentum #L.fermentum #Probiotics #Microbiome#Microorganisms#Microbes #GutMicrobiome #GutMicrobiota

#분유 #영유아 #영아 #유아 #감염 #락토바실러스퍼멘텀 #L.퍼멘텀 #프로바이오틱스 #유익균 #마이크로바이옴 #장내미생물 #장내미생물총 #장내미생물군

[출처: Maldonado,J., Cañabate, F., Sempere, L., Vela, F., Sánchez, A. R., Narbona, E., ... &Lara-Villoslada, F. (2012). Human milk probiotic Lactobacillus fermentumCECT5716 reduces the incidence of gastrointestinal and upper respiratory tractinfections in infants. Journal of pediatric gastroenterology and nutrition, 54(1), 55-61.]

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[Lactobacillus fermentum] Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

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Metabolic Screening Analysis Service