[Gut Microbiome] The contributory role of gut microbiota in cardiovascular disease

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Thecontributory role of gut microbiota in cardiovascular disease

W.H. Wilson Tangand Stanley L. Hazen

Department ofCellular and Molecular Medicine, Lerner Research Institute, and Department ofCardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic,Cleveland, Ohio, USA.

Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/ phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota–dependent formation of TMA and host hepatic flavin monooxygenase 3– dependent (FMO3-dependent) formation of TMA–N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.

제목

심혈관 질환에 기여하는 장내 미생물의 역할

내용

우리 팀은 최근 트리메틸아민 (trimethylamine)의 일부분인콜린 (choline) 및 포스파티딜 콜린 (phosphatidylcholine)그리고 L-카르니틴 (L-carnitine)을함유한 특정 식이 영양소가 죽상경화성 (atherosclerotic) 심장 질환의 발병에 기여한다는사실을 발견했다. 메타 유기체 (Meta-organismal)의경로는 장내 미생물에 의존한 TMA 형성, 숙주 내 간(肝)의 플라빈 모노산소첨가효소 3 (flavinmonooxygenase 3; FMO3)에 의존한 TMA-N-oxide (TMAO) 형성, 죽상동맥경화증 (atherosclerosis)에 기계적으로 연결되어있는 것으로 보이는 대사산물을 포함한 것으로 밝혀졌으며, 각 수준은 심혈관 질환 (CVD)의 위험과 강한 연관이 있다. 종합적으로, 이러한 연구들은 정립된 메타 유기체 경로에 따른 영양 전구체, 장내미생물 및 관련 요인들(host participants)이 CVD의예방 및 치료를 위한 새로운 표적이 될 수 있음을 나타낸다.

Figure 2. Effects of gut microbiota–dependent TMAO production

on cholesterol and sterol metabolism and atherosclerosis.

콜레스테롤과 스테롤(sterol) 대사및 죽상경화증에 대한 장내 미생물 의존 TMAO 생산의 효과

(TheJournal of Clinical Investigation, 2014)

Keywords

: #Trimethylamine #Phosphatidylcholine #Choline #L-carnitine #Atherosclerosis #CardiovascularDisease #CVD #AtheroscleroticHeartDisease #TMA #TMA–N-oxide #Probiotics #Microbiome#Microorganisms#Microbes #Microbiota #GutMicrobiome #GutMicrobiota

#트리메틸아민 #포스파티딜콜린 #콜린 #엘카르니틴 #죽상경화증 #심혈관계질환 #심혈관질환 #죽상경화성심장질환 #프로바이오틱스 #유익균 #마이크로바이옴 #미생물총 #미생물군 #미생물유전자 #장내미생물 #장내미생물총 #장내미생물군

[출처: Tang, W.W., & Hazen, S. L. (2014). The contributory role of gut microbiota incardiovascular disease. The Journal of clinical investigation, 124(10), 4204-4211.]

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