[Saccharomyces cerevisiae] Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in ...

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Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever

Flaviano S. Martinsa,b, Samir D.A. Elianb, Angélica T. Vieiraa, Fabiana C.P. Tiagob, Ariane K.S. Martinsb, Flávia C.P. Silva b, Éricka L.S. Souzab, Lirlândia P. Sousac, Helena R.C. Araújod, Paulo F. Pimentad, Cláudio A. Bonjardimb, Rosa M.E. Arantese, Mauro M. Teixeiraa, Jacques R. Nicoli b,∗

Abstract

Salmonella spp. are Gram-negative, facultative, intracellular pathogens that cause several diarrheal diseases ranging from self-

limiting gastroenteritis to typhoid fever. Previous results from our laboratory showed that Saccharomyces cerevisiae strain UFMG

905 isolated from ‘cachac¸ a’ production presented probiotic properties due to its ability to protect against experimental infection

with Salmonella enterica serovar Typhimurium. In this study, the effects of oral treatment with S. cerevisiae 905 were evaluated at

the immunological level in a murine model of typhoid fever. Treatment with S. cerevisiae 905 inhibited weight loss and increased

survival rate after Salmonella challenge. Immunological data demonstrated that S. cerevisiae 905 decreased levels of

proinflammatory cytokines and modulated the activation of mitogenactivated protein kinases (p38 and JNK, but not

ERK1/2), NF-B and AP-1, signaling pathways which are involved in the transcriptional activation of proinflammatory mediators.

Experiments in germ-free mice revealed that probiotic effects were due, at least in part, to the binding of Salmonella to the yeast.

In conclusion, S. cerevisiae 905 acts as a potential new biotherapy against S. Typhimurium infection due to its ability to bind

bacteria and modulate signaling pathways involved in the activation of inflammation in a murine model of typhoid fever.

제목

내용

그람음성균인 Salmonella spp. 통각성의 세포 내 병원체로서 자가 제한성 위장염에서 장티푸스에 이르기까지 여러 가지 설사병을 유발한다. 우리 실험실의 이전 결과는 '까까샤(cachaça)'생산에서 분리 된 Saccharomyces cerevisiae strain UFMG 905가 Salmonella enterica serovar Typhimurium에 의한 감염을 방어 할 수 있기 때문에 프로바이오틱 성질을 가지고 있음을 밝혀냈다. 이 연구에서 S. cerevisiae 905에 의한 구강 치료의 효과는 장티푸스 쥐 모델의 면역학적 수준에서 평가되었다. S. cerevisiae 905로 처리하면 살모넬라에 의한 체중 감소와 생존율 증가가 억제되었다. 면역 데이터는 S. cerevisiae 905가 전 염증성 사이토카인의 수준을 감소 시켰으며, mitogen-activated protein kinase (p38 및 JNK, ERK1/2는 아님), NF-κB 및 AP-1, 염증매개체의 전사 활성화를 포함하는 신호 전달 경로를 조절했다. 무균 생쥐에서 실험 한 결과, 살모넬라가 효모에 결합하는데 적어도 부분적으로는 프로바이오틱 효과가 있다고 밝혀졌다. 결론적으로, S.cerevisiae 905는 박테리아와 결합하여 장티푸스 모델의 쥐 모델의 염증 활성화에 관여하는 신호 전달 경로를 조절할 수 있기 때문에 S.Typhimurium 감염에 대한 잠재적인 새로운 생물 요법으로 작용한다.

[출처 : F.S.Martinsetal./InternationalJournalofMedicalMicrobiology301 (2011) 359–364]

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[Saccharomyces cerevisiae] Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in ...

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