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[Gut Microbiome] The microbiome and innate immunity

e 2082

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The microbiome and innate immunity

Christoph A. Thaiss, Niv Zmora, Maayan Levy & EranElinav

Department of Immunology, Weizmann Institute of Science,Rehovot 76100, Israel. Division of Internal Medicine,

Tel Aviv Sourasky MedicalCenter, Tel Aviv 64239, Israel. Research Center for Digestive Tract and LiverDiseases,

Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.

The intestinal microbiome is a signaling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host’s metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host–microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

제목

마이크로바이옴(미생물군)과 선천성 면역

내용

장내 미생물군은 식이 요법과 같은 환경적 투입 요인을 유전적 신호 및 면역 신호와 통합하여 숙주의 신진대사,면역

및 감염 반응에 영향을 끼치는 신호 중심지(signalinghub)이다.선천성 면역계의 조혈 및 비조혈 세포는

숙주-마이크로바이옴 인터페이스에 전략적으로 위치해 있다.이러한 세포들은 미생물 또는 미생물의 대사산물을

감지하고 그 신호를 숙주 생리 반응 및 미생물 생태계의 조절로 해석하는 능력을 갖고 있다.선천성 면역계와 장내

미생물 간의 의사소통에서 발생하는 이상 현상은 복잡한 질병의 원인이 될 수 있다.

Figure 1. Intestinalepithelial cells orchestrate the host–microbiota interface.

장내 상피 세포는 숙주-미생물 인터페이스를 조율한다. (Nature,2016)

Figure 2. The integration ofmicrobial signals by myeloid cells

골수 세포에 의한 미생물 신호의 통합 (Nature,2016)

Figure 4. The hierarchy ofanatomy in microbiome–innate immune system interactions.

미생물군-선천성 면역계 상호작용에서의 해부학 계층 구조. (Nature,2016)

Figure 5. Microbiome–innate-immune-systeminteractions are involved in multifactorial diseases.

미생물군-선천성 면역계 상호작용은 다인성 질병에 연루된다. (Nature,2016)

Keywords

: #Microbiome#Microorganisms #GutMicrobiome #GutMicrobiota #IntestinalMicrobiome #Immunity#InnateImmunity #InnateImmuneSystem #Diet #Metabolism #Host-Microbiome#MetabolicProducts #MicrobialEcology

#마이크로바이옴#미생물#미생물총#미생물군#장내미생물#장내미생물군#장내미생물총#면역#면역계#선천면역#선천성면역#선천성면역계#식이요법#대사과정#숙주마이크로바이옴#숙주미생물군#대사산물#미생물생태계

[출처: Thaiss, C. A., Zmora, N., Levy, M.,& Elinav, E. (2016). The microbiome and innate immunity. Nature, 535(7610), 65.]

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㈜마이크로바이옴은 생명공학 최고의 기술력을 바탕으로 마이크로바이옴 산업의 성장과 발전의 선도적 역할을 하고 있는 대한민국 대표 마이크로바이옴 R&D 전문 기업입니다.

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상품에 대하여 공동연구개발 및 기술이전을 통하여 공동특허 출원과 마이크로바이옴 상품화에 성공하였고, 마이크로바이옴 글로벌 기업이 되기 위하여 연구개발을 지속하고 있습니다.

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[Gut Microbiome] The microbiome and innate immunity

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