Antimicrobial and antiadhesive properties of a biosurfactant isolated from Lactobacillus paracasei ssp.paracasei A20
E.J. Gudin ˜a, V. Rocha, J.A. Teixeira and L.R. Rodrigues
Abstract
Lactobacillus paracasei ssp. paracasei A20 against several micro-organisms, including Gram-positive and Gram-negative bacteria, yeasts and filamentous fungi. Methods and Results: Antimicrobial and antiadhesive activities were determined using the microdilution method in 96-well culture plates. The biosurfactant showed antimicrobial activity against all the micro-organisms assayed, and for twelve of the eighteen micro-organisms (including the pathogenic Candida albicans, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus agalactiae), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were achieved for biosurfactant concentrations between 25 and 50 mg ml)1. Furthermore, the biosurfactant showed antiadhesive activity against most of the micro-organisms evaluated. Conclusions: As far as we know, this is the first compilation of data on antimicrobial and antiadhesive activities of biosurfactants obtained from lactobacilli against such a broad group of micro-organisms. Although the antiadhesive activity of biosurfactants isolated from lactic acid bacteria has been widely reported, their antimicrobial activity is quite unusual and has been described only in a few strains. Significance and Impact of the Study: The results obtained in this study regarding the antimicrobial and antiadhesive properties of this biosurfactant opens future prospects for its use against micro-organisms responsible for diseases and infections in the urinary, vaginal and gastrointestinal tracts, as well as in the skin, making it a suitable alternative to conventional antibiotics.
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제목 Antimicrobial and antiadhesive properties of a biosurfactant isolated from Lactobacillus paracasei ssp.paracasei A20 내용 이 연구의 목적은 Lactobacillus paracasei ssp로부터 분리 된 생물학적 계면 활성제의 그람양성 균 및 그람음성 박테리아, 효모 및 사상 균류를 비롯한 여러 미생물에 대한항균 및 항 점착성을 결정하는 것이다. 생물학적 계면 활성제는 분석 된 모든 미생물에 대해 항균 활성을 보였고, 18개의 미생물 (병원성 칸디다균, 대장균, 포도상 구균, 표피 포도 알균 및 연쇄상 구균을 포함) 중 12 개에 대해 최소 저해 농도 최소 살균 농도 (MBC)는 생물학적 계면 활성제 농도가 25~50 mg/ml인 경우 달성되었다. 또한, 생물계면활성제는 평가된 대부분의 미생물에 대해 항 점착 활성을 보였다. 이 연구에서 얻은 결과는 기존 항생제의 대안으로 생체 계면 활성제의 항균성 및 항 점착성과 관련하여 향후 비뇨기, 질 및 위장관뿐만 아니라 피부에서 질병 및 감염을 담당하는 미생물에 대한 사용 가능성을 열었다. [출처 : Journal compilation ª 2010 The Society for Applied Microbiology, Letters in Applied Microbiology 50 (2010) 419–424 ] |
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