[Lactobacillus casei] Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study

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Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study
A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial

D Merenstein 1 , M Murphy 1 , A Fokar 2 , RK Hernandez 2 , H Park 1 , H Nsouli 2 , ME Sanders 3 , BA Davis 4 , V Niborski 5 , F Tondu 5 and NM Shara 2,6

Abstract

Background:

To evaluate whether a fermented dairy drink containing the probiotic strain Lactobacillus casei DN-114 001 could reduce the incidence of common infectious diseases (CIDs) and the change of behavior because of illness in children.
Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3–6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days.
Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report).

Results:

The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio ¼ 0.81, 95% CI: 0.65, 099) P ¼ 0.046.

Conclusions:

Daily intake of a fermented dairy drink containing the probiotic strain L. casei DN-114 001 showed some promise in reducing overall incidence of illness, but was primarily driven by gastrointestinal infections and there were no differences in change of behavior.
European Journal of Clinical Nutrition (2010) 64, 669–677; doi:10.1038/ejcn.2010.65; published online 19 May 2010

제목

Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial

배경

probiotic strain Lactobacillus casei DN-114 001을 함유 한 발효 유제품 음료가 어린이의 질병으로 인한 일반적인 감염성 질환(CID)의 발병률 및 행동 변화를 감소시킬 수 있는지 평가하였다.

대상자/방법

우리는 워싱턴 DC 대도시 지역에서 이중맹검, 무작위, 위약 대조를 은닉할당 임상 시험을 실시했다. 참가자는 탁아소/학교에서 638명의 3-6세 아동이었다. 시작은 90일 연속으로 생균을 배양하지 않은 특정 probiotic 균주 또는 일치하는 위약을 함유 한 발효 유제품 음료이다. 두 가지 주요 결과가 평가되었다 : 질병으로 인한 CID 발생 및 행동 변화 (둘 다 부모 보고서로 평가)

결과

질병으로 인한 행동 변화의 속도는 활동군과 대조군간에 유사했다. 그러나 활성군 (0.0782)의 CID 발생률은 대조군(0.0986)의 발생률보다 19% 낮은 것으로 나타났다 (발생률 비율은 0.581, 95% CI: 0.65,099).

결론: 프로바이오틱 균주인 L.casei DN-114 001을 함유 한 발효 유제품 음료의 일일 섭취는 질병의 전반적인 발병율을 감소시킬 것으로 기대 되었으나 주로 위장관 감염의 유발을 감소시켰으며 행동 변화에는 차이가 없었다.

[출처 : European Journal of Clinical Nutrition]

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[Lactobacillus casei] Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study

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