커뮤니티

학술자료

Academic Material

로그인

[Gut Microbiome] Acetate mediates a microbiome–brain–β cell axis to promote metabolic syndrome

e 2203

모바일 App 사용자에게는 실시간 전송!

Acetate mediates a microbiome–brain–β cell axis to promotemetabolic syndrome

Rachel J. Perry, Liang Peng,Natasha A. Barry, Gary W. Cline, Dongyan Zhang,Rebecca L. Cardone, Kitt Falk Petersen,Richard G. Kibbey, Andrew L. Goodman &Gerald I. Shulman

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown.

Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae.

Together, these findings identify increased acetate production resulting from a nutrient–gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.

제목

아세트산염(Acetate)는 미생물군-뇌-베타세포 축을 매개하여 대사증후군을 촉진한다.

내용

비만, 인슐린 저항성 및 대사증후군은 장내 미생물의 변화와 관련 있다.그러나 장내 미생물 변화가 이러한 상태들에

이르게 할 수 있다는 메커니즘에 대해서는 알려진 바가 없다.본 연구에서 우리는 설치류 내 장내 미생물 변화에 의한

아세트산염 생성의 증가가 부교감신경계의 활성화를 유도하고,이는 결국 포도당 자극에 의한 인슐린 분비의 증가,

그렐린 분비의 증가,과식증,비만 및 관련 후유증을 촉진한다는 것을 보여준다.동시에,이러한 연구 결과는 영양분과

장내 미생물의 상호작용 및 뒤따르는 부교감 활성화에서 기인한 아세트산염 생산 증가를 비만에 대한 가능한 치료

목표로 여긴다.

Extended Data Figure 1.

Mechanism by which adiet–microbiota interaction drives obesity and the metabolic syndrome.

확장된 데이터 그림 1. 식이요법-미생물 상호작용이 비만과 대사증후군을 일으키는 메커니즘 (Nature, 2016)

Keywords

: #Acetate #Gut-BrainAxis#Microbiome-Brain-βcellAxis #MetabolicSyndrome #Microbiome #GutMicrobiome#GutMicrobiota #Obesity #InsullinResistance #IR #ParasympatheticNervousSystem#Insulin #Ghrelin #Hyperphagia #Nutrient–GutMicrobiotaInteraction

#아세트산염 #아세테이트 #장뇌축 #미생물-뇌-베타세포축 #대사증후군 #마이크로바이옴 #미생물군 #미생물총

#장내미생물 #장내미생물총 #장내미생물군 #비만 #인슐린저항성 #부교감신경 #인슐린 #그렐린 #과식 #과식증

#영양분-장내미생물상호작용

[출처: Perry, R. J., Peng, L., Barry, N. A.,Cline, G. W., Zhang, D., Cardone, R. L., ... & Shulman, G. I. (2016).Acetate mediates a microbiome–

brain–β-cell axis to promote metabolic syndrome. Nature, 534(7606), 213.]

㈜마이크로바이옴

http://microbiomekorea.co.kr/

㈜마이크로바이옴은 생명공학 최고의 기술력을 바탕으로 마이크로바이옴 산업의 성장과 발전의 선도적 역할을 하고 있는 대한민국 대표 마이크로바이옴 R&D 전문 기업입니다.

㈜마이크로바이옴은 생명공학 국가연구기관인 한국생명공학연구원과 마이크로바이옴 관련

상품에 대하여 공동연구개발 및 기술이전을 통하여 공동특허 출원과 마이크로바이옴 상품화에 성공하였고, 마이크로바이옴 글로벌 기업이 되기 위하여 연구개발을 지속하고 있습니다.

F T

목록으로

오늘 0 / 전체 60

no.		제목	조회수

20	[Gut Microbiome] The microbiome and innate immunity	2082
19	[Gut Microbiome] Acetate mediates a microbiome–brain–β cell axis to promote metabolic syndrome	2203
18	[Gut Microbiome] The New Era of Treatment for Obesity and Metabolic Disorders: Evidence and Expectations for Gut Microbiome Transplantation	2032
17	[Gut Microbiome] The Gut Microbiome in Human Neurological Disease: A Review	2536
16	[Gut Microbiome] Rapidly expanding knowledge on the role of the gut microbiome in health and disease	2180
15	[Lactobacillus Plantarum] Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-α	2222
14	[Lactobacillus paracasei] Decreased Fat Storage by Lactobacillus Paracasei Is Associated with Increased Levels of Angiopoietin-Like 4 Protein (ANGPTL4)	2415
13	[Lactobacillus paracasei] Effect of LactobacillusparacaseiST11 on a nasal provocation test with grass pollen in allergic rhinitis	2359
12	[Lactobacillus paracasei] Antimicrobial and antiadhesive properties of a biosurfactant isolated from Lactobacillus paracasei ssp.paracasei A20	2441
11	[Lactobacillus Plantarum] Cholesterol-lowering effects of a putative probiotic strain Lactobacillus plantarum EM isolated from kimchi	2459
10	[Bacillus] Anti-inﬂuenza Activity of a Bacillus subtilis Probiotic Strain	2119
9	[Bacillus] Aflatoxin B1 degradation by Bacillus subtilis UTBSP1 isolated from pistachio nuts of Iran	2273
8	[Lactobacillus Plantarum] Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells	2349
7	[Lactobacillus casei] Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers	3239
6	[Bacillus]Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity	2125
5	[Lactobacillus casei] Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study	2340
4	[Saccharomyces cerevisiae] A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome.	2297
3	[Saccharomyces cerevisiae] Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in ...	2112
2	[Lactobacillus casei] Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial	2077
1	[Saccharomyces cerevisiae] Saccharomyces cerevisiae Modulates Immune Gene Expressions and Inhibits ETEC-Mediated ERK1/2 and p38 Signaling Pathways in Intestinal Epithelial Cell	2403

㈜마이크로바이옴 ㅣ 서울시 서대문구 연희로 77-12 영화빌딩2층

Tel :02-322-0302 l Fax : 02-322-0759

학술자료

Academic Material﻿

[Gut Microbiome] Acetate mediates a microbiome–brain–β cell axis to promote metabolic syndrome

Academic Material